hahaahhaah
bem que desisti que postar a foto toda, iria ser levado extreme
ainda mais que eu estou com a camisa do poderoso coringão ai
hahaahhaah
bem que desisti que postar a foto toda, iria ser levado extreme
ainda mais que eu estou com a camisa do poderoso coringão ai
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O efeito não é irreversível.
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Kara, sobre o implante é simplesmente ridículo, basta ver as fotos do antes e depois.
Depois de pesquisar muito sobre o assunto, procurei o dermatologista e me foi prescrito finasterida 1mg (não confudir com a versão de 5mg utilizada no tto de hpb) e isso foi há 5 anos.Pela visão do mesmo foi me passado que a melhor forma de SEGURAR e FREAR(isso mesmo, não existe essa mágica de nascer cabelo novo) seria o uso da finasterida.Sinceramente, nunca senti nenhum desses efeitos colaterais, acredito muito no poder psicológico de quem toma ser influenciado a sentir tais efeitos, tipo se não houvesse esse sensacionalismo barato em torno da finasterida os efeitos indesejáveis de diminuição da libido seriam menores do q os 3%(isso mesmo, essa grande porcentagem lol).
E quanto aos efeitos irreversíveis não há relatos(com comprovação cientifica) e a na bula do fármaco é bem claro que os efeitos cessam com a parada do uso do mesmo.
Como estudante de medicina o meu raciocinio: O mecanismo de ação da Finasterida é a inibição da enzima 5-alpha-redutase q por sua vez converte a testosterona em diidrotestosterona(dht) q provavelmente é o mecanismo q desenvolve a alopecia androgenética.Então teoricamente vc teria mais testosterona livre com o uso da fina.Enfim, eu acredito que sendo acompanhado com responsabilidade por um profissional médico qualificado o tratamento é válido sim.
Quanto ao leu na veja é q os sabidões aí do assunto provavelmente leram uma matéria da veja sobre a finasterida, totalmente desprovida de nexo e coerência.
Enfim, é a minha opinião baseada na minha experiência, na experiência de outros e nas minhas pesquisas com relação ao assunto.
Espero que tenha ajudado.
Última edição por m.martins22; 27-08-2014 às 02:09.
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um ponto que deve ser levado em consideração é que tem corpos que vão reagir de formas meio diferentes aos medicamentos ne
outra coisa importante é que o hormonio testosterona é considerado o hormonio do sucesso, da vitoria ,quanto mais a pessoa se sente vencedora, ruladora, a quantidade desse hormonio no corpo aumenta.
e careca é pura genética né, apesar que depois dos 30 a inteligencia na conversa tem mais peso que a juventude,nisso em geral eu acho que nós machos progredimos para melhor, com o tempo o macho fica mais inteligente enquanto que a mulherada tende a ficar mais complexada, mais insegura
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Ainda não sou doutor, sou estudante.
Me mostre artigos cientificos com evidências que comprovam que a finasterida 1mg utilizada no tratamento de alopécia androgenética possui efeitos colaterais irreversíveis.
Segundo a ISHRS(aposto que você não conhece) não há EVIDÊNCIAS do ponto de vista CIENTÍFICO que justifiquem o vínculo entre a fina e os persistentes efeitos colaterais.
Síndrome pós finasterida, lol
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Dra. Cíntia Cunha | Finasterida, Mitos e Verdades!
Calvície precoce tem solução segura - Paraná-Online - Paranaense como você
Alguns links que servem como tira dúvidas sobre a finasterida, seus colaterais e o tto da calvície de um modo geral
Lembrando que não quero passar minha opinião como verdade absoluta e universal, entretanto pra MIM vem dando muito certo
Mais uma vez, espero ter ajudado
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o problema do transplante é o preço, praticamente um carro popular zero, so se for muito rico mesmo ne
sobre os efeitos da finan, já vi relatos desses efeitos que baixam a libidos nos foruns carecais também, mas não é todo mundo, teve um la que falou que o esperma fica fino, imagina a zueira ne
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Cara poe Sindrome pos finasterida ou em inglês Post finasteride Syndrome e verá vários relatos, tem até uma fundação americana pra arrecadar fundos pra tratar isso.
Alguma coisa tem, não ia ter tanta coisa a toa, não tem nada ver isso de psicológico.
A chance é mínima mas existe, e é um risco muito caro a correr.
Achei esses dois estudos:
Outros:"Níveis de neuro esteróides ativos estão modificados no fluído cérebro-espinhal e plasma em pacientes pós Finasterida que apresentam efeitos sexuais persistentes e depressão/ansiedade."
Roberto Cosimo Melcangi, PhD,
Donatella Caruso, PhD,
Federico Abbiati, PhD Student,
Silvia Giatti, PhD,
Donato Calabrese, PhD Student,
Fabrizio Piazza, PhD,† and Guido Cavaletti, MD†‡
Neuroactive Steroid Levels are Modified in Cerebrospinal Fluidand Plasma of Post-Finasteride Patients Showing PersistentSexual Side Effects and Anxious/Depressive Symptomatology
The Journal of Sexual Medicine
Neuroactive Steroid Levels are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology - Melcangi - 2013 - The Journal of Sexual Medicine - Wiley Online Libr
"Finasterida: Efeitos sexuais persistentes em grupo de indivíduos."
Irwig MS and Kolukula S
J Sex Med 2011;8:1747–1753.
Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss - Irwig - 2011 - The Journal of Sexual Medicine - Wiley Online Library
FDA-Mandated Labeling Changes for Finasteride
A revision to the Propecia label to include libido disorders, ejaculation disorders, and orgasm disorders that continued after discontinuation of the drug.
A revision to the Proscar label to include decreased libido that continued after discontinuation of the drug.
A revision to both the Propecia and Proscar labels to include a description of reports of male infertility and/or poor semen quality that normalized or improved after drug discontinuation.”O implante bem feito acho que fica bom, tipo o Rooney ficou de boa na minha opinião.Our research definitely concludes that PFS is real.
For a subset of these men, the damage persists—maybe forever—even after they go off the drug.
We don’t fully understand why, but it is as if something shuts off biologically, and stays that way.“
— Dr. Abdulmaged M. Traish, PhD, Professor of Biochemistry at Boston University School of Medicine: Men’s Health (November 2011)
I have recently seen an increasing number of men who have developed significant degrees of clinical hypogonadism – low sex drive, erectile dysfunction, reduced sexual sensations and listlessness, fatigue and/or ‘brain fog’ – while either taking finasteride or after stopping the medication, even long after stopping it.
… If high normal levels of testosterone, combined with low estrogen levels, does not relieve the hypogonadal symptoms, then the possibility that the man has some resistance to testosterone must be considered.”
— Dr. Alan Jacobs, Neuroendocrinologist: A Neuroendocrine Approach To Finasteride Side Effects In Men (April 2010)
Hardly a week goes by that I am not being approached by yet another young man recently prescribed Propecia as a “treatment” for male pattern baldness.
This drug has the capacity to obliterate their sexuality, not just for the time that they take the drug, but for all time.
This vanity treatment can and does condemn many young men to a life sentence of sexual anhedonia, without feeling, desire or function, to otter misery and despair for which, as yet, we have no treatment.”
— Dr. Andrew Rynne, Irish Medical Council: Benign Prostatic Hyperplasia (March 2011)
We are becoming more and more aware of persistent sexual health problems occurring as a result of the use of 5 alpha reductase inhibitors, finasteride, and dutasteride, in a subset of patients.
What is even more alarming is that in addition to persistent sexual issues, there are persistent central cognitive issues and concerns of persistent depression.”
— Dr. Irwin Goldstein, Editor-in-Chief, Journal of Sexual Medicine: An Old Problem with a New Cause—5-Alpha Reductase Inhibitors and Persistent Sexual Dysfunction (July 2011)
It’s been very frustrating for a lot of these men because they’ve sought care from medical professionals who are unaware of the risk of persistent and serious sexual dysfunction since it was not originally suggested in the literature.
… Finasteride is different because it can actually change the brain’s chemistry. The enzyme 5-alpha reductase is present in many areas of the brain.
It is rare for a drug to have the capability to persistently change the brain’s chemistry.”
— Dr. Michael Irwig, F.A.C.E., Assistant Professor of Medicine, George Washington University School of Medicine: Doctors link hair growth drug to sexual dysfunction, depression and cancer (Feburary 2012)
Several young men seen for hypogonadism (low libido, erectile dysfunction, low energy, etc) after using finasteride have been found to have low-normal levels of bio-available testosterone and LH.
This leads to the question of whether partial androgen resistance is at play.”
— Dr. Alan Jacobs, Neuroendocrinologist: A Proposed Mechanism For Prolonged Sexual Side Effects From Finasteride (June 2010)
Última edição por Mothafoxx; 28-08-2014 às 12:27.
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Dear Dr Jacobs,
Don´t waste your time trying to find the causes of this severe problem. The real cause is demyelination of the motor neurons in the spinal chord,not only the mental side effects but also the sexual side effects are a result of the neurological damage from finasteride.
You can read it here:
Finasteride and Neurological Damage : Mental Side Effects
And here:
Hair Loss Help Forums - Finasteride and Neurological Damage
"Demyelination just happend because of a lack of allopregnanolone which is synthesized by 5AR2 (yes, type 2 and only type 2!!) in the spinal chord and not because of an immune response"
"But neurodegeneration can happen over many years. And I bet they didn't check for demyelination. I think that most people taking finasteride over the years will experience neurological damage (demyelination) in the spinal chord. It's just that for some it happens in a shorter timeframe and for others it develops during several years"
"The brain has 5AR1 but the spinal chord has mainly 5AR2. Finasteride only inhibits 5AR2. I said the CONDITION at the spinal chord is the same. It's not a real case of MS though since the brain is not as strongly affected of 5AR2 inhibition as the spinal chord. But I personally still think the brain is somewhat affected from peripheral neurosteroid inhibition although not as much as the spinal chord neurons.
This also explains why these neurological effects appear years after finasteride usage. It takes a longer period of time of allopregnanolone depletion for neurodegeneration to occur.
The symptoms of "brain fog" are definitely the same as demyelination of spinal chord motor neurons, as written in my first post. "
------------
This theory is from Alex Miller who is a biologist (specialization track: neurology and neurological sciences). I have tried to find his contact info but have had no success. As you may know finasteride side effects are not well-known yet there are no direct scientific studies about this theory but there is strong evidence and arguments that support it, so anyone who conducts a study about this theory will prove well. Even using other scientific studies (Poletti et al. 2003), (William H. Theodore, MD; Clinical Epilepsy Section NIH Bethesda, MD) will reach to the same conclusion:
Here it is the theory that Alex Miller and others are supporting:
Before starting the research, I already knew that 5-alpha-reductase (5AR) has important functions in the central nervous system (CNS). So inhibiting it (by finasteride) might induce some side effects there. I will not address the possible sexual side effects but only the neurological ones. I will explain to you all what I have come up with so far. And guys: this is not looking good at all.
First of all, 5AR exists in two different isozymes: 5AR type 1 (5AR1) and 5AR type 2 (5AR2). 5AR1 is present mainly in the brain, muscle, liver and in sebaceous glands. 5AR2 is referred to as the "peripheral 5AR" since it is present mainly in the prostate, seminal vesicles, liver and hair follicles. Finasteride is a specific type 2 inhibitor and doesn't inhibit 5AR1 in significant amounts. But here comes something that not many people know: 5AR type 2 is also expressed in very significant amounts in spinal chord motor neurons, actually in similar amounts found in the prostate (Poletti et al. 2003) and could have (damn it!: WILL have) an effect there. What kind of effect this is, will be explained soon.
Something else, that many people don't know: Both isozymes of 5AR have more functions than just Testosterone (T) -> Dihydrotestosterone (DHT) conversion. They do the following conversions:
1. Testosterone -> Dihydrotestosterone
2. Progesterone -> Dihydroprogesterone
3. Deoxycorticosterone -> Dihydrodeoxycorticosterone
The latter two conversions are also inhibited by finasteride and so the production of neuroactive steroids is inhibited, since their metabolic pathway continues like this:
Dihydroprogesterone -> Tetrahydroprogesterone or also called Allopregnanolone.
Dihydrodeoxycorticosterone -> tetrahydrodeoxycorticosterone
These converions are catalyzed by an enzyme called 3-alpha hydroxysteroid dehydrogenase (3-alpha HSD).
You can read about these neuroactive steroids on wikipedia in order to get a rough idea about them:
Tetrahydrodeoxycorticosterone
Allopregnanolone
Altough it states there, that Tetrahydrodeoxycorticosterone is synthesized by 5AR1 in the brain, this is only partially true since, as explained above 5AR2 is also present in the CNS namely in the motor neurons of the spinal chord.
Now we come to the REAL concern: The inhibition of Allpregnanolone production. Altough Allopregnanolone can be produced in the brain by 5AR1, the CNS is also dependent on peripheral 5AR2. I quote from "Implications of neuroimaging for the treatment of epilepsy":
"Allopregnanolone formed in peripheral tissues readily enters the brain where it acts to enhance activation of GABA. A receptors" (William H. Theodore, MD; Clinical Epilepsy Section NIH Bethesda, MD).
Now to repeat again: Finasteride definitely inhibits allopregnanolone production in spinal chord motor neurons where mainly 5AR2 is present and also reduces allopregnanolone levels in the brain and other parts of the CNS since these parts are dependent on peripheral 5AR2 conversion of progesterone to dihydroprogesterone which is then converted to allopregnanolone by 3-alpha HSD.
The question is what the result of long-term allopregnanolone depletion is. Before you have to understand what the myelin-sheath of neurons is. The axon of neurones (both, peripheral neurons and neurons in the CNS) are surrounded by an electrically insulating layer: the myelin sheath. This is vital for fast and efficient impulse propagation on the neurons. I don't want to go into details here. Fact is: Allopregnanolone has vital function in the myelination of neurons as seen in the following studies:
When you read these, you'll see that the metabolic pathway of progesterone (inhibited by finasteride...) is vital for myelination and other functions in the CNS. In fact there are dozens of studies about the effects of progesterone metabolism and allopregnanolone on myelination.
1. Progestins and antiprogestins: mechanisms of action, neuroprotection and myelination (Link)
2. Progesterone: Therapeutic opportunities for neuroprotection and myelin repair (Link)
Quote: "Progesterone and its metabolites promote the viability of neurons in the brain and spinal cord. ".
Oh damn it! Didn't we say just before, that the motor neurons of the spinal chord expresses mainly 5AR type 2 (inhibited by finasteride)? So there will be a negative effect of myelination there for sure!
2. Allopregnanolone treatment, both as a single injection or repetitively, delays demyelination and enhances survival of niemann-pick C mice (Link)
3. There is also a study of Goumari et al. (didn't find it on the net) that shows the function of allorpegnanolone in myelination. Quote: "... allopregnanolone accelerated myelination ..." (Ghoumari et al. 2003b)
Alright. Let's see what the effects of demyelination are: Read Myelin . The most worrying effect is again demyelination of the motor neurons of the spinal chord which will be the effect of long term finasteride use:
"Sub-acute combined degeneration of the spinal cord secondary to pernicious anaemia can lead to anything from slight peripheral nerve damage to severe damage to the central nervous system affecting speech, balance and cognitive awareness. When myelin degrades, conduction of signals along the nerve can be impaired or lost and the nerve eventually withers."
Do you see those symptoms? Speech is affected, balance and cognitive awareness. This is exactly what you call brain fog here. The question is wheter this effect is reversable if you take finasteride for years. I certainly hope so for my friend altough, you know, neurogegeneration can really be irreversible.
It has to be said, that these effects are of LONG-TERM use but probably WILL eventually happen after years of finasteride use.
------------------------------------------
Here there are some studies that talk about demyelination and the lack of Allopregnanolone:
1) Progestins and antiprogestins: mechanisms of action, neuroprotection and myelination - Springer
Progestins and antiprogestins: mechanisms of action, neuroprotection and myelination
2) Progesterone: Therapeutic opportunities for neuroprotection and myelin repair
Progesterone: Therapeutic opportunities for neuroprotection and myelin repair
3) Allopregnanolone treatment, both as a single injection or repetitively, delays demyelination and enhances survival of niemann-pick C mice
Allopregnanolone treatment, both as a single injection or repetitively, delays demyelination and enhances survival of niemann-pick C mice
Pronto, ta bão ou quer mais?
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